Natural small molecules as inhibitors of coronavirus lipid-dependent attachment to host cells: a possible strategy for reducing SARS-COV-2 infectivity?
Identifieur interne : 000463 ( 2020/Analysis ); précédent : 000462; suivant : 000464Natural small molecules as inhibitors of coronavirus lipid-dependent attachment to host cells: a possible strategy for reducing SARS-COV-2 infectivity?
Auteurs : Mirko Baglivo [Italie] ; Manuela Baronio [Italie] ; Giuseppe Natalini [Italie] ; Tommaso Beccari [Italie] ; Pietro Chiurazzi [Italie] ; Ezio Fulcheri [Italie] ; Paolo Pietro Petralia [Italie] ; Sandro Michelini [Italie] ; Giovanni Fiorentini [Italie] ; Giacinto Abele Miggiano [Italie] ; Assunta Morresi [Italie] ; Gerolamo Tonini [Italie] ; Matteo Bertelli [Italie]Source :
- Acta bio-medica : Atenei Parmensis [ 2531-6745 ] ; 2020.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (), Antiviraux (pharmacologie), Antiviraux (usage thérapeutique), Attachement viral (), Bibliothèques de petites molécules (pharmacologie), Bibliothèques de petites molécules (usage thérapeutique), Humains, Infections à coronavirus (traitement médicamenteux), Lipides, Pneumopathie virale (traitement médicamenteux).
- MESH :
- pharmacologie : Antiviraux, Bibliothèques de petites molécules.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : Antiviraux, Bibliothèques de petites molécules.
- Animaux, Antiviraux, Attachement viral, Humains, Lipides.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Antiviral Agents (therapeutic use), Betacoronavirus (drug effects), Betacoronavirus (physiology), Coronavirus Infections (drug therapy), Humans, Lipids, Pneumonia, Viral (drug therapy), Small Molecule Libraries (pharmacology), Small Molecule Libraries (therapeutic use), Virus Attachment (drug effects).
- MESH :
- chemical , chemistry : Antiviral Agents.
- chemical , pharmacology : Antiviral Agents, Small Molecule Libraries.
- chemical , therapeutic use : Antiviral Agents, Small Molecule Libraries.
- drug effects : Betacoronavirus, Virus Attachment.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- physiology : Betacoronavirus.
- Animals, Humans, Lipids.
Abstract
Viral infectivity depends on interactions between components of the host cell plasma membrane and the virus envelope. Here we review strategies that could help stem the advance of the SARS-COV-2 epidemic.
DOI: 10.23750/abm.v91i1.9402
PubMed: 32191676
Affiliations:
Links toward previous steps (curation, corpus...)
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- to stream Ncbi, to step Merge: 003432
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- to stream Ncbi, to step Checkpoint: 003432
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- to stream Main, to step Curation: 000463
- to stream Main, to step Exploration: 000463
- to stream 2020, to step Extraction: 000463
Links to Exploration step
pubmed:32191676Le document en format XML
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Istituto Giannina Gaslini, Genova, Italy. ezio.fulcheri@unige.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pathology Division of Anatomic Pathology Dept. of Surgical and Diagnostic Sciences (DISC) University of Genova, Italy; UOSD Fetal Pathology and Ginecology IRCCS . Istituto Giannina Gaslini, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Petralia, Paolo Pietro" sort="Petralia, Paolo Pietro" uniqKey="Petralia P" first="Paolo Pietro" last="Petralia">Paolo Pietro Petralia</name><affiliation wicri:level="1"><nlm:affiliation>Institute G. Gaslini, Children's Hospital, Genova, Italy. paolo.petralia@anspi.net.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute G. Gaslini, Children's Hospital, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Michelini, Sandro" sort="Michelini, Sandro" uniqKey="Michelini S" first="Sandro" last="Michelini">Sandro Michelini</name><affiliation wicri:level="3"><nlm:affiliation>Department of Vascular Rehabilitation, San Giovanni Battista Hospital, Rome, Italy. s.michelini@acismom.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Vascular Rehabilitation, San Giovanni Battista Hospital, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Fiorentini, Giovanni" sort="Fiorentini, Giovanni" uniqKey="Fiorentini G" first="Giovanni" last="Fiorentini">Giovanni Fiorentini</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacy Fiorentini, Brescia, Italy. mirko.baglivo@assomagi.org.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pharmacy Fiorentini, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Miggiano, Giacinto Abele" sort="Miggiano, Giacinto Abele" uniqKey="Miggiano G" first="Giacinto Abele" last="Miggiano">Giacinto Abele Miggiano</name><affiliation wicri:level="3"><nlm:affiliation>Human Nutrition Research Center, Sacro Cuore Catholic University, Rome, Italy. 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Giuseppe.natalini@poliambulanza.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Anaesthesia and Intensive Care, Fondazione Poliambulanza, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Beccari, Tommaso" sort="Beccari, Tommaso" uniqKey="Beccari T" first="Tommaso" last="Beccari">Tommaso Beccari</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy. tommaso.beccari@unipg.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pharmaceutical Sciences, University of Perugia, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Chiurazzi, Pietro" sort="Chiurazzi, Pietro" uniqKey="Chiurazzi P" first="Pietro" last="Chiurazzi">Pietro Chiurazzi</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Genomic Medicine, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy. pietro.chiurazzi@unicatt.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Genomic Medicine, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Fulcheri, Ezio" sort="Fulcheri, Ezio" uniqKey="Fulcheri E" first="Ezio" last="Fulcheri">Ezio Fulcheri</name><affiliation wicri:level="1"><nlm:affiliation>Pathology Division of Anatomic Pathology Dept. of Surgical and Diagnostic Sciences (DISC) University of Genova, Italy; UOSD Fetal Pathology and Ginecology IRCCS . Istituto Giannina Gaslini, Genova, Italy. ezio.fulcheri@unige.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pathology Division of Anatomic Pathology Dept. of Surgical and Diagnostic Sciences (DISC) University of Genova, Italy; UOSD Fetal Pathology and Ginecology IRCCS . Istituto Giannina Gaslini, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Petralia, Paolo Pietro" sort="Petralia, Paolo Pietro" uniqKey="Petralia P" first="Paolo Pietro" last="Petralia">Paolo Pietro Petralia</name><affiliation wicri:level="1"><nlm:affiliation>Institute G. Gaslini, Children's Hospital, Genova, Italy. paolo.petralia@anspi.net.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute G. Gaslini, Children's Hospital, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Michelini, Sandro" sort="Michelini, Sandro" uniqKey="Michelini S" first="Sandro" last="Michelini">Sandro Michelini</name><affiliation wicri:level="3"><nlm:affiliation>Department of Vascular Rehabilitation, San Giovanni Battista Hospital, Rome, Italy. s.michelini@acismom.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Vascular Rehabilitation, San Giovanni Battista Hospital, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Fiorentini, Giovanni" sort="Fiorentini, Giovanni" uniqKey="Fiorentini G" first="Giovanni" last="Fiorentini">Giovanni Fiorentini</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacy Fiorentini, Brescia, Italy. mirko.baglivo@assomagi.org.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pharmacy Fiorentini, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Miggiano, Giacinto Abele" sort="Miggiano, Giacinto Abele" uniqKey="Miggiano G" first="Giacinto Abele" last="Miggiano">Giacinto Abele Miggiano</name><affiliation wicri:level="3"><nlm:affiliation>Human Nutrition Research Center, Sacro Cuore Catholic University, Rome, Italy. GiacintoAbele.Miggiano@unicatt.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Human Nutrition Research Center, Sacro Cuore Catholic University, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Morresi, Assunta" sort="Morresi, Assunta" uniqKey="Morresi A" first="Assunta" last="Morresi">Assunta Morresi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy. assunta.morresi@unipg.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Tonini, Gerolamo" sort="Tonini, Gerolamo" uniqKey="Tonini G" first="Gerolamo" last="Tonini">Gerolamo Tonini</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, Fondazione Poliambulanza, Brescia, Italy. gerolamotonini@libero.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Surgery, Fondazione Poliambulanza, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Bertelli, Matteo" sort="Bertelli, Matteo" uniqKey="Bertelli M" first="Matteo" last="Bertelli">Matteo Bertelli</name><affiliation wicri:level="1"><nlm:affiliation>MAGI-Euregio, Bolzano, Italy; EBTNA-Lab, Rovereto (TN), Italy. matteo.bertelli@assomagi.org.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>MAGI-Euregio, Bolzano, Italy; EBTNA-Lab, Rovereto (TN)</wicri:regionArea><wicri:noRegion>Rovereto (TN)</wicri:noRegion></affiliation></author></analytic><series><title level="j">Acta bio-medica : Atenei Parmensis</title><idno type="eISSN">2531-6745</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (chemistry)</term><term>Antiviral Agents (pharmacology)</term><term>Antiviral Agents (therapeutic use)</term><term>Betacoronavirus (drug effects)</term><term>Betacoronavirus (physiology)</term><term>Coronavirus Infections (drug therapy)</term><term>Humans</term><term>Lipids</term><term>Pneumonia, Viral (drug therapy)</term><term>Small Molecule Libraries (pharmacology)</term><term>Small Molecule Libraries (therapeutic use)</term><term>Virus Attachment (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux ()</term><term>Antiviraux (pharmacologie)</term><term>Antiviraux (usage thérapeutique)</term><term>Attachement viral ()</term><term>Bibliothèques de petites molécules (pharmacologie)</term><term>Bibliothèques de petites molécules (usage thérapeutique)</term><term>Humains</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Lipides</term><term>Pneumopathie virale (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Small Molecule Libraries</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term><term>Small Molecule Libraries</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Betacoronavirus</term><term>Virus Attachment</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Bibliothèques de petites molécules</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Bibliothèques de petites molécules</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Lipids</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Antiviraux</term><term>Attachement viral</term><term>Humains</term><term>Lipides</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Viral infectivity depends on interactions between components of the host cell plasma membrane and the virus envelope. Here we review strategies that could help stem the advance of the SARS-COV-2 epidemic.</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Latium</li></region><settlement><li>Rome</li></settlement></list><tree><country name="Italie"><noRegion><name sortKey="Baglivo, Mirko" sort="Baglivo, Mirko" uniqKey="Baglivo M" first="Mirko" last="Baglivo">Mirko Baglivo</name></noRegion><name sortKey="Baronio, Manuela" sort="Baronio, Manuela" uniqKey="Baronio M" first="Manuela" last="Baronio">Manuela Baronio</name><name sortKey="Beccari, Tommaso" sort="Beccari, Tommaso" uniqKey="Beccari T" first="Tommaso" last="Beccari">Tommaso Beccari</name><name sortKey="Bertelli, Matteo" sort="Bertelli, Matteo" uniqKey="Bertelli M" first="Matteo" last="Bertelli">Matteo Bertelli</name><name sortKey="Chiurazzi, Pietro" sort="Chiurazzi, Pietro" uniqKey="Chiurazzi P" first="Pietro" last="Chiurazzi">Pietro Chiurazzi</name><name sortKey="Fiorentini, Giovanni" sort="Fiorentini, Giovanni" uniqKey="Fiorentini G" first="Giovanni" last="Fiorentini">Giovanni Fiorentini</name><name sortKey="Fulcheri, Ezio" sort="Fulcheri, Ezio" uniqKey="Fulcheri E" first="Ezio" last="Fulcheri">Ezio Fulcheri</name><name sortKey="Michelini, Sandro" sort="Michelini, Sandro" uniqKey="Michelini S" first="Sandro" last="Michelini">Sandro Michelini</name><name sortKey="Miggiano, Giacinto Abele" sort="Miggiano, Giacinto Abele" uniqKey="Miggiano G" first="Giacinto Abele" last="Miggiano">Giacinto Abele Miggiano</name><name sortKey="Morresi, Assunta" sort="Morresi, Assunta" uniqKey="Morresi A" first="Assunta" last="Morresi">Assunta Morresi</name><name sortKey="Natalini, Giuseppe" sort="Natalini, Giuseppe" uniqKey="Natalini G" first="Giuseppe" last="Natalini">Giuseppe Natalini</name><name sortKey="Petralia, Paolo Pietro" sort="Petralia, Paolo Pietro" uniqKey="Petralia P" first="Paolo Pietro" last="Petralia">Paolo Pietro Petralia</name><name sortKey="Tonini, Gerolamo" sort="Tonini, Gerolamo" uniqKey="Tonini G" first="Gerolamo" last="Tonini">Gerolamo Tonini</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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